Spiteri graduated in music studies from the University of Malta and studied jazz with Dave Frank and Dan Haerle. He co-wrote Porn the musical which won Best New Musical at the Off West End Theatre Awards and was critic’s choice in Time Out London. He also musically directed the Fm Productions adaptations of Hairspray, Fiddler on the Roof and numerous pantomimes by Fm productions and Masquerade. In 2012 and 2015 Spiteri directed and wrote the band arrangements for the national concerts of Animae gospel choir. With his jazz trio Noir he recorded the album Till you switch off the lights and played at the Malta Jazz Festival and at the My Unique Jazz festival in Berlin. Also in Berlin the performed with Andrea Marcelli and Roberto Badoglio. Kris wrote words and music for Kafena's album Lukanda Propaganda and he features in Nadine Axisa's album Velvet and in Red Electrick's Inside you. Spiteri is a director of Tunin’ Entertainment and also performs with the working band known as The Residents.